How to Set auto responder / Out of office replay in Zimbra Mail server

You can set Out of office replay in zimbra for specific account.

Set Out of Office reply for specific Account
Syntax:
command option Account_name attribute 'Message here'
Example:
$ zmprov ma shahzad@example.com zimbraPrefOutOfOfficeReply 'I am Out of Office right now, For immediate assistance please contact at support@example.com'

Enable Out of Office 
$ zmprov ma shahzad@example.com zimbraPrefOutOfOfficeReplyEnabled TRUE

Now Test by sending mail from other user, you will get a auto reply message. If you want to disable Auto reply message , change TRUE to FALSE